Every medicinal product is a combination of drug substance and various excipients which are indispensible components comprising the greater proportion of dosage unit. Therefore, the knowledge of the composition, function and behavior of excipients is important for the successful design, development and manufacturing of pharmaceutical dosage form. In present work the effect of four different diluents namely starch, microcrystalline cellulose, mannitol and calcium sulphate dihydrate on the release of theophylline from an immediate release tablet has been studied. The physicochemical properties such as hardness, thickness, friability, uniformity of weight and the drug content of the formulated tablets and in- vitro drug dissolution study were evaluated.
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